IOCB Prague

Robert Hanus Group

Chemical Ecology
Research Group
Senior
BIO cluster

About our group

Our research focuses on chemical ecology: we investigate the chemical identity, biological functions, biosynthesis, and evolutionary origins of small molecules that organisms use to interact with their environment.
Our primary model organisms are termites, ancient and ecologically important social insects. We study the chemistry and biological roles of their chemical signals and defensive compounds, the evolution and function of the enzymes involved in their biosynthesis, and their detection by the sense of smell.
Our interdisciplinary team combines chemical and biological approaches, including chemical analysis, behavioral studies, electrophysiology, biochemistry, and molecular genetics, including next-generation sequencing (NGS) of genomes and transcriptomes.
We also investigate broader aspects of termite biology, including breeding systems, ecology, physiology, and chemical taxonomy. Beyond termites, our research explores chemical ecology across a diverse range of animals, from arthropods to humans.

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Publications

All publications
Expansion of the geranylgeranyl pyrophosphate synthase gene family underlies the evolution of terpenoid biosynthesis in termites
PLOS Biology 24 (4): e3003648 (2026)
Termites produce the most diverse array of terpenoids among terrestrial metazoans, comprising over 200 structures. However, their biosynthesis has not yet been elucidated. Here, we identify a gene family which arose through a series of duplications of geranylgeranyl pyrophosphate synthase in the common ancestor of Neoisoptera, the terpene-producing termite lineage. We functionally characterized several proteins from this rich GGPPS-like family as terpene synthases generating biologically relevant sesqui- and diterpenes. These include the queen pheromone (3R,6E)-nerolidol in Embiratermes neotenicus and the presumed precursor of polycyclic defensive diterpenes (E,E,E)-neocembrene in Nasutitermes takasagoensis. We report significant enrichment of transposable elements in the GGPPS-like genomic loci, study the selection pressures acting in the evolution of the GGPPS-like family, and highlight an amino acid site crucial for cyclization capacity and enantiospecificity of the characterized…
Evolution of Linoleic Acid Biosynthesis Paved the Way for Ecological Success of Termites
Molecular Biology and Evolution 40 (4): msad087 (2023)
Long-lived termite kings and queens activate telomerase in somatic organs
Proceedings of the Royal Society B - Biological Sciences 288 (1949): 20210511 (2021)